Morphologically determined scale of alzheimer's disease stages: «the tomography dementia rating scale» (TDR)

DOI: https://doi.org/10.25512/DIR.2012.06.4.03

For quoting:
Maksimovich I.V. "Morphologically determined scale of alzheimer's disease stages: «the tomography dementia rating scale» (TDR)". Journal Diagnostic & interventional radiology. 2012; 6(4); 23-32.

authors:

Maksimovich I.V.

keywords:

Alzheimer's disease

AD stages

dementia

TDR

CDR

hippocampus

atrophy of the temporal lobes of the brain

Abstract:

Aim. For determination of Alzheimer's disease (AD) stages, we offer a morphologically determined scale - The Tomography Dementia Rating scale (TDR) based on the severity of atrophic changes in the temporal lobes of the brain revealed during CT and MRI. Materials and methods. The research involved 140 patients aged 28-79. The Test Group included 81 patients aged 34-79 with AD various stages. The Control Group included 59 patients aged 28-78 with various types of brain lesions accompanied by manifestations of dementia and cognitive impairment, but not suffering from AD.

Results. CT and MRI data allowed to compose the TDR scale determining the severity of atrophic changes in the temporal lobes at each AD stage:

• Pre-clinical AD stage TDR-0: temporal lobes atrophy with 4-8% tissue mass decrease (26-28 MMSE points).

• Early AD stage - mild dementia TDR-1: temporal lobes atrophy with 9-18% tissue mass decrease (corresponds to CDR-1; 20-25 MMSE points).

• Middle AD stage - mild dementia TDR-2: temporal lobes atrophy with 19-32% tissue mass decrease (corresponds to CDR-2; 12-19 MMSE points).

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